Urinary Care

UPR

Cranberry Concentrate 500 mg

Cranberry power against recurring UTIs.

UPR provides 500 mg of cranberry concentrate rich in proanthocyanidins (PACs), which help stop bacteria such as E. coli from attaching to the urinary tract wall.

Capsule6 × 10 capsules per boxJV with Tensall Bio-Tech, Taiwan

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Composition

Cranberry concentrate powder 500 mg
Flavonoids — proanthocyanidins (PACs)
Flavonols — quercetin, myricetin
Phenolics — benzoic acid
Organic acids — quinic acid, malic acid, citric acid

Indications

Prevention & treatment of UTI
Protect against recurrence of UTI
Promote genitourinary health
Enhance immune system
Improve digestive system

How it works

Mechanism of action of cranberry

Urinary inhibitors of bacterial adherence.
Competitive inhibitors of attachment to uroepithelial cells — cranberry PACs block the P-fimbriae that E. coli uses to cling to cells.
Acidify urine pH.
Escherichia coli, Staphylococcus saprophyticus, Klebsiella, Enterococcus and Proteus mirabilis are the main causal agents of UTI. Antibiotic treatment can disrupt the balance of uro-genital microflora, so recurrence is common.

Dosage & safety

Dosage & administration

Regular: 2 capsules daily
Intensive: 4 capsules daily

Usage in pregnancy: No known teratogenic effect has been reported.
Contraindication: No known contraindication.
Interaction: No known drug interaction.
Presentation: 6 × 10 capsules per box
Storage: Store at room temperature and avoid direct exposure to sunlight.

Use as directed by a registered physician. Read the package insert before use. Keep out of reach of children.

Clinical evidence

Cranberry extract vs. low-dose trimethoprim in recurrent UTI

137 older women with two or more antibiotic-treated UTIs in the previous 12 months were randomised to 500 mg cranberry extract or 100 mg trimethoprim for 6 months. 39 participants had an antibiotic-treated UTI (25 cranberry, 14 trimethoprim; relative risk 1.616, 95% CI 0.93–2.79, P = 0.084). Time to first recurrence was not significantly different between groups (84.5 vs 91 days, P = 0.479). The authors concluded trimethoprim had a very limited advantage over cranberry extract and more adverse effects, and that cranberry extract carries no risk of antimicrobial resistance or super-infection.

Trial registration ISRCTN80031108

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Questions about UPR? Email info@centurybangla.com.bd.

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